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Two Diabetes Drugs Do Not Appear to Increase CV Risk in Type 2 Diabetes

Two studies presented at the ADA 75th Scientific Sessions assessed the cardiovascular safety of the diabetes drugs lixisenatide and sitagliptin in patients with type 2 diabetes. Findings indicated that neither drug did not increase CV risk in this patient population.

In the highly anticipated ELIXA study, he glucagon-like peptide-1 (GLP-1) receptor agonist lixisenatide appears to have a neutral effect on heart failure and other cardiovascular (CV) outcomes.

Likewise, data from the TECOS trial showed that the dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin did not appear to increase the risk for CV events or hospitalization for heart failure in patients with type 2 diabetes and established heart disease.

Watch the video and read the full articles on the ELIXA study and the TECOS trial.
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Udayakabadi commented on August 13, 2015
Unfortunately, cardiovascular safety is looked at as no increase in CV outcomes despite lowering of A1c. We have forgotten that UKPDS,the ' Gold Standard ' longest duration study has shown that intensive therapy with SUs actually lowered CV outcomes by 16 %.